OLIGONOL® is a potent antioxidant ingredient made from highly-absorbable, low molecular weight lychee polyphenols. Clinical studies have demonstrated the efficacy of OLIGONOL® in the fields of overweight/metabolic syndrome (regulation of blood lipids and glycemia), sport nutrition (prevention of heat stress and inflammation, improvement of blood flow), as well as anti-aging (prevention of skin glycation). OLIGONOL® can be used  as functional food (dietary supplements, drinks) but also as cosmetic ingredient in topical formulations for anti-aging. OLIGONOL® is currently in registration phase in the EU, please contact us to stay updated!



Polyphenols are known for their antioxidant effects, however they usually consist in long-chain products that are poorly absorbed by the organism. In contrast, OLIGONOL® contains low molecular weight catechin-type monomers and proanthocyanidins, extracted from lychee fruits (Litchi chinensis) by a proprietary manufacturing process. Assimilation of these small compounds was shown by clinical studies to be three times higher than that of conventional, unprocessed polyphenols.



Research evidence has shown the benefits of OLIGONOL® in the context of metabolic syndrome, a condition affecting overweight people and characterized by systemic inflammation, dyslipidemia, hyperglycemia and high blood pressure. OLIGONOL® improves blood lipids and glycemia, and reduces the levels of oxidative stress markers.



The properties of OLIGONOL® are of particular interest in the field of sport nutrition. Intense exercise results in heat stress associated with release of pro-inflammatory compounds, as well as generation of free radicals which increase oxidative stress. Both are reduced in athletes consuming OLIGONOL®, leading to better and faster recovery. Besides, OLIGONOL® improves blood flow to the muscles, which allows better removal of toxins.




Due to its potent antioxidant effects, OLIGONOL® is an ingredient of choice for anti-aging formulations. OLIGONOL® is suitable for both food supplements and topical formulations. Studies have shown that application of OLIGONOL skin cream was able to improve skin appearance (wrinkle depth, spots) and prevent glycation of collagen, a major contributor to skin aging.



Sakurai et al. 2008. Antioxidative effects of a new lychee fruit-derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes. Biosci Biotechnol Biochem. vol. 72(2), pp. 463-76.

Lee et al. 2010. The effect of Oligonol intake on cortisol and related cytokines in healthy young men. Nutr Res Pract. vol. 4(3), pp. 203-7.

Park et al. 2014. Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice. J Nutr. vol. 144(8), pp. 1150-7.

Ahn et al. 2015. Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell. Nutr Res Pract. vol. 9(2), pp. 123-8.

Park et al. 2016. Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway. Nutr Res Pract. vol. 10(1), pp. 3-10.

Liu et al. 2017. Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1. Nutrients vol. 9(9).